![]() Data were analyzed from June 1, 2021, to March 15, 2022. Associations between BRAF variants and targeted therapy response were tested in 6 BRAF-variant, patient-derived organoid lines and in 3 of the patient donors of those lines. Univariate and multivariate analyses were performed using Cox proportional hazards regression. The Kaplan-Meier method and log-rank test were used to compare overall survival (OS) and disease-free survival (DFS). Whole-exome sequencing, targeted sequencing, and Sanger sequencing were performed to identify BRAF variants. Objective To explore the association of BRAF variant subtypes with disease characteristics, prognosis, and targeted therapy response in patients with ICC.ĭesign, Setting, and Participants In this cohort study, 1175 patients who underwent curative resection for ICC from January 1, 2009, through December 31, 2017, were evaluated at a single hospital in China. Importance BRAF variants are associated with tumor progression however, the prevalence of BRAF variant subtypes and their association with disease characteristics, prognosis, and targeted therapy response in patients with intrahepatic cholangiocarcinoma (ICC) are largely unknown.
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